Table of Contents
Metal-Based Drugs
Volume 6, Issue 1, Pages 31-40
http://dx.doi.org/10.1155/MBD.1999.31

Characterisation and In Vitro Cytotoxicity of Triorganophosphinegold(I) 2-Mercaptobenzoate Complexes

1Medical Department, Pharmachemie B.V., Haarlem NL-2003 RN, The Netherlands
2Department of Chemistry, The University of Adelaide, Adelaide 5005, Australia

Received 21 January 1999; Accepted 27 January 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The preparation and full NMR (H1,C13andP31) characterisation of three R3PAu (2mba) complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2-mercaptobenzoic acid is reported. An interesting solvent dependence in the 1H spectra is rationalised in terms of competing intra- and inter-molecular hydrogen bonding. An X-ray analysis of the [Ph3PAu(2mba)] species reveals a linear P—Au—S arrangement and association in the lattice via the familar carboxylic acid dimer motif. The in Vitro cytotoxicity against seven human tumout lines is also described. The complexes display moderate to very high activity. Particularly noteworthy is their greater activity against the H226 cell line (non-small cell lung cancer) compared with that displayed by a range of cytotoxic drugs.