Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 4-5, Pages 271-276
http://dx.doi.org/10.1155/MBD.1999.271

Biologically-Active Gold(III) Complexes

Department of Chemistry, UMIST, Manchester M60 1QD, UK

Received 8 September 1998; Accepted 30 September 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A review is given of the background to and results of the succesful pharmacological testing of [AuX2(damp)] (X = Cl, OAc; damp = 2Me2NCH2C6H4) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR-1-75. These are the first fully evaluated gold(III) complexes. The activity and reactions of the diacetato-complex bear a resemblance to cisplatin, and some of the relevant chemistry is discussed. Preliminary screening data for C,P-chelated tertiary phosphine derivatives of gold(III) are presented.