A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H =
6-Thioguanine

Crump, David; Siasios, George; Tiekink, Edward R. T.

doi:https://doi.org/10.1155/MBD.1999.361

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Volume 6 |Article ID 576438 | https://doi.org/10.1155/MBD.1999.361

David Crump, George Siasios, Edward R. T. Tiekink, "A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine", Metal-Based Drugs, vol. 6, Article ID 576438, 8 pages, 1999. https://doi.org/10.1155/MBD.1999.361

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine

David Crump,¹ George Siasios,² and Edward R. T. Tiekink²

¹AMRD Operations Pty Ltd, 576 Swan Street, Australia

²Department of Chemistry, The University of Adelaide, Australia

Received04 Oct 1999

Accepted12 Oct 1999

Abstract

The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy3PAu(6-MP)] and [Et3PAu(6-TG)].

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Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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