A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: (S), R = Ph, Cy, E
t; SH = 6-Mercaptopurine and R = E t; SH =
The antitumour activities of four triorganophosphinegold(I) thiolates, (R) [R = Ph, Cy, Et; SH = 6-mercaptopurine and R Et; SH = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of and .
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