A Study of the Antitumour Activity of Four
Triorganophosphinegold(I) Thiolates: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>R</mml:mtext><mml:mtext>3</mml:mtext></mml:msub><mml:mtext>PAu</mml:mtext></mml:math>(S<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>R</mml:mtext><mml:mo>′</mml:mo></mml:msup></mml:math>), R = Ph, Cy, E<small.letters>t</small.letters>; S<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>R</mml:mtext><mml:mo>′</mml:mo></mml:msup></mml:math>H = 6-Mercaptopurine and R = E<small.letters>t</small.letters>; S<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>R</mml:mtext><mml:mo>′</mml:mo></mml:msup></mml:math>H =
6-Thioguanine

Crump, David; Siasios, George; Tiekink, Edward R. T.

doi:https://doi.org/10.1155/MBD.1999.361

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Volume 6 | Article ID 576438 | https://doi.org/10.1155/MBD.1999.361

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine

David Crump,¹George Siasios,²and Edward R. T. Tiekink²

Received04 Oct 1999

Accepted12 Oct 1999

Abstract

The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(S′R) [R = Ph, Cy, Et; SR′H = 6-mercaptopurine and R Et; SR′H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy3PAu(6-MP)] and [Et3PAu(6-TG)].

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Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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