Table of Contents
Metal-Based Drugs
Volume 6, Issue 4-5, Pages 239-245
http://dx.doi.org/10.1155/MBD.1999.239

Silver and Gold NMR

Department of Biochemistry, Molecular Biology and Biophysics, Medical School, University of Minnesota, 5-130 BSBE, Building, 312 Chumh Street SE, Minneapolis 55455, MN, USA

Received 18 December 1998; Accepted 19 February 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Silver and gold, together with copper, form the transition metal group IB elements in the periodic table and possess very different nuclear magnetic resonance (NMR) spectroscopic properties. While there is only one gold isotope (A197u) , which has a spin of 3/2 and therefore a quadrupole moment, silver occurs in two isotopic forms (A107g and A109g ), both of which have a spin 12 and similar NMR spectroscopic properties. The unfavorable properties of gold have prevented its NMR spectroscopic investigation thus far. On the other hand, there are several reports of silver NMR. However, the low sensitivity of silver, combined with its long relaxation times have rendered the direct detection of silver possible only with concentrations greater than a few tenth molar. Reviewed here are the general limitations of silver NMR and some techniques to partially overcome these limitations, as well as a summary of currently available chemical shift and scalar coupling data on A109g .