Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 3, Pages 177-182
http://dx.doi.org/10.1155/MBD.1999.177

Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

1Department of Chemistry, University of Pune, Pune 411007, India
2National Centre for Cell Science, Ganeshkhind, Pune 411007, India
3CLRC Daresbury, Cheshire WA4 4AD, UK
4Department of Chemistry, University of Hull, Hull HU6 7RX, UK

Received 31 March 1999; Accepted 30 April 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-β -hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl2] followed by [Cu(TATSC)Cl2] and the ligand in compariosn with cisplatin.