Table of Contents
Metal-Based Drugs
Volume 7, Issue 3, Pages 129-131

Zinc(II) Complexes - A New Group of Non-Mutagenic Herpes Simplex Virus Inhibitors

1Department of Genetics, Faculty of Biology, Sofia University, Sofia 1421, Bulgaria
2Laboratory of Virology, Faculty of Biology, Sofia University, Sofia 1421, Bulgaria

Received 30 March 2000; Accepted 5 May 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)2 and Zn(asp)2, are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti-HSV drugs, further studies on their mutagenicity are of particular interest. In the present paper we present data showing that Zn(pic)2 and Zn(asp)2 do not express mutagenic effect in both prokaryotic (Salmonella typhimurium) and eukaryotic (Saccharomices cerevisiae) test systems.