Table of Contents
Metal-Based Drugs
Volume 7, Issue 2, Pages 89-100

Development of Acid-Sensitive Platinum(II) Complexes With Protein-Binding Properties

1Institute of Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Straße 31, Freiburg 79104, Germany
2Tumor Biology Center, Department of Medical Oncology, Clinical Research, Breisacher Straße 117, Freiburg 79106, Germany

Received 29 November 1999; Accepted 17 December 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Four new protein-binding platinum(II) complexes, 10, 11, 21, 22, in which the dichloroplatinum moiety is coordinated either to a carbon-substituted or a nitrogen-substituted ethylene diamino ligand, were prepared in ten-step syntheses. According to pH-dependent stability studies with strictly related compounds, 11 and 22 exhibit acid-sensitive properties.