Table of Contents
Metal-Based Drugs
Volume 7, Issue 4, Pages 185-193
http://dx.doi.org/10.1155/MBD.2000.185

Insights Into the Mode of Action of the Anti-Candida Activity of 1,10-Phenanthroline and its Metal Chelates

1Chemistry Department, National University of Ireland Maynooth, Maynooth, Co.m, Kildare, Ireland
2Dublin Institute of Technology, Cathal Brugha Street, Dublin, Ireland
3Biochemistry Department, Trinity College, Dublin, Ireland

Received 11 September 2000; Accepted 20 September 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metal complexes of malonie acid (metal = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were prepared and only the Ag(I) complex inhibited the growth of Candida albicans. Malonate complexes incorporating the chelating 1,10-phenanthroline (1,10-phen) ligand showed a range of activities: good (Mn(II), Cu(II), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal-free 1,10-phen and Ag(CH3CO2) were also highly active. The metal-free non-chelating ligands 1,7- phenanthroline and 4,7-phenanthroline were inactive and the Cu(II), Mn(II) and Zn(II) complexs of 1,7-phen displayed only marginal activity. Whereas the Cu(II) malonate/1,10-phen complex induces significant cellular oxidative stress the Zn(II) analogue does not.