Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
Kira Rubina,1Edgars Abele,1Pavel Arsenyan,1Ramona Abele,1Maris Veveris,1and Edmunds Lukevics1
Abstract
Silicon and germanium containing heteroaromatic sulfides have been prepared using
phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18-
crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (β-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(β-triphenylsilylethyl)
silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and
vasodilating agents.