Targeting Estrogen Receptor Sites in Human Breast Cancer Cell Line T47D With Copper Conjugates of Nonsteriodal Anti-inflammatory Drug Derivatives: Antiproliferative Activity                          
of Ketoprofen Derivative and its Copper Complex

Saha, Dilip Kumar; Padhye, Shreelekha; Padhye, Subhash

doi:https://doi.org/10.1155/MBD.2001.73

Metal-Based Drugs

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Volume 8 | Article ID 510932 | https://doi.org/10.1155/MBD.2001.73

Targeting Estrogen Receptor Sites in Human Breast Cancer Cell Line T47D With Copper Conjugates of Nonsteriodal Anti-inflammatory Drug Derivatives: Antiproliferative Activity of Ketoprofen Derivative and its Copper Complex

Dilip Kumar Saha,¹Shreelekha Padhye,¹and Subhash Padhye¹

Received21 Feb 2001

Accepted14 Mar 2001

Abstract

A square planar copper complex of derivatized NSAID drug (Ketoprofen thiosemicarbazone [3-benzoyl-α -methyl benzene acetic acid thiosemicarbazone]), is characterized by elemental analysis, spectroscopy, electrochemistry and magnetic susceptibility studies which exhibits dose-dependent and enhanced antiproliferative effects on human breast cancer cell line T47D rich in progesterone receptors.

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Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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