Table of Contents
Metal-Based Drugs
Volume 8 (2001), Issue 3, Pages 137-143

Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Universita degli Studi, Dipartimento di Chimica, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Florence 50121, Italy

Received 12 June 2000; Accepted 18 June 2000

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed Schiff bases have shown to be more antibacterial against one more bacterial species as compared to uncomplexed Schiff-bases.