Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent
macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial
effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm
morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and
biochemical parameters of reproductive organs have been examined and discussed. The resulting biologically
active [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII
and X = Cl or NO3) type of
complexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts and
different diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elemental
analyses, molecular weight determinations and conductivity measurements. The mode of bonding was
established on the basis of IR, H1 NMR, C13 NMR, Pt195 NMR, Pb207 NMR, XRD and electronic spectral
studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged
by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium and
platinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral
geometry is suggested for lead complexes.
