Table of Contents
Metal-Based Drugs
Volume 8, Issue 4, Pages 199-210
http://dx.doi.org/10.1155/MBD.2001.199

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N-substituted Naphthylethylimidazoline

1Laboratoire d'Hétérochimie Fondamentale et Appliquée, UMR 5069 du CNRS, Université Paul Sabatier, 118, route de Narbonne, Toulouse cedex 4 F-31062, France
2Service de Radioprotection de I'EDF, 22-28, rue Joubert, Paris F-75009, France
3I.T.O.D.Y.S. Université de Paris VII, Associé au CNRS, 1, rue Guy de la Brosse, Paris F-75005, France
4Unité de Radioprotection, Centre de Recherche du Service de Santé des Armées, 24, avenue des Maquis du Grésivaudan, La Tronche cedex F-38702, France

Received 13 December 2001; Accepted 17 December 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A number of organosilicon and organogermanium derivatives and some related compounds including the N-substituted. 2-[1-naphthylmethyl]-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and the toxicity of some compounds have been determined in mice. In this paper we report the synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium, compounds such as sila- and germadithioacetals derived from N-substituted naphthylimidazolne.