Table of Contents
Metal-Based Drugs
Volume 8 (2001), Issue 2, Pages 79-84
http://dx.doi.org/10.1155/MBD.2001.79

Cytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate

1Molecular Structure Corporation, 9009 New Trails Drive, The Woodlands, Texas 77381-5290, USA
2Department of Chemistry, The University of Adelaide, 5005, Australia
3Medical Department, Pharmachemie B.V., Haarlem NL-2003, The Netherlands

Received 6 March 2001; Accepted 23 March 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 – 2500 ng/ml).