Cytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate

Vincent, Beverly R.; Clarke, David J.; Smyth, Douglas R.; de Vos, Dick; Tiekink, Edward R. T.

doi:https://doi.org/10.1155/MBD.2001.79

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Volume 8 | Article ID 696395 | https://doi.org/10.1155/MBD.2001.79

Cytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate

Beverly R. Vincent,¹David J. Clarke,²Douglas R. Smyth,²Dick de Vos,³and Edward R. T. Tiekink²

Received06 Mar 2001

Accepted23 Mar 2001

Abstract

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 – 2500 ng/ml).

Copyright

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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