Table of Contents
Metal-Based Drugs
Volume 8 (2002), Issue 5, Pages 263-267

Antibacterial Role of SO42 , NO3 , C2O42 and CH3CO2 Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan
3University of Florence, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Rm 188, Polo Scientifico , Firenze 50019-Sesto Fiorentino, Italy

Received 8 February 2002; Accepted 19 February 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A condensation reaction of 2-amino-1,3,4-thiadiazole with 2-pyrrolecarboxaldehyde to form tridentate NNN donor Schiff base has been performed. The prepared Schiff base was further used for the formation of metal complexes having stoichiometry [M(L)2]Xn , where M=Cu(II) or Zn(II), L=N-(2-pyrrolylmethylene)-2-amino-1,3,4-thiadiazole, X=SO42 , NO3 , C2O42 or CH3CO2 and n=1 or 2. The new compounds described here have been characterized by their physical, spectral and analytical data, and have been screened against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of the Schiff base increased upon chelation/complexation, having the same metal ion (cation) but different anions opening up a novel approach in finding new ways to fight against antibiotic resistant strains.