M. Kidwai, R. Venkataramanan, B. Dave, "Antifungal Activity of Solventlessly Synthesized Organomercurials", Metal-Based Drugs, vol. 8, Article ID 196271, 3 pages, 2002. https://doi.org/10.1155/MBD.2002.283
Antifungal Activity of Solventlessly Synthesized Organomercurials
A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time reduced from hours to minutes. The prepared compounds were tested against and for their antifungal activity and were found to posses good activity.
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