Table of Contents
Metal-Based Drugs
Volume 8 (2002), Issue 5, Pages 283-285
http://dx.doi.org/10.1155/MBD.2002.283

Antifungal Activity of Solventlessly Synthesized Organomercurials

Department of Chemistry, University of Delhi, Delhi 110007, India

Received 21 January 2002; Accepted 4 February 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K2CO3 under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time reduced from hours to minutes. The prepared compounds were tested against A.niger¯ and A.flavous¯ for their antifungal activity and were found to posses good activity.