Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and
manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with
malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The
complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic,
magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the
formation of the complexes [M(N4Ln)Cl2]
(M = Fe(lI) or Mn(II)). All these complexes are stable and
monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the
octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and
testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in
mating trials and biochemical parameters of reproductive organs have been examined and discussed.
