The in vitro antifungal activity of compounds 1-3 ({[(CH3)2NCH2]2C6H3}R2SnX; (where X=Cl, R=n-Bu
for 1, X=Br, R=n-Bu for 2 and x=PF6, R=n=Bu for 3)) was estimated with the help of a modified
microdilution format of the M27-A guidelines and was compared with in vitro activity of their
diphenyltin(IV) analogues 4 and 5 (where X=Br, R=Ph for 4 and X=PF6, R=Ph for 5), and of drugs currently
in clinical use (ketoconazole, fluconazole and amphotericin B). It was found that in coordinating solvents the
more soluble derivative 2 is less active than the phenyl one (4), and compounds 1 and 3 are even inactive.In this paper, the in vitro antitumour activity of ionic diphenyltin(IV) complexes 4 and 5 against seven
tumoural cell lines of human origin is also reported. The preparation and characterization (H1, C13 and Sn119
NMR spectroscopy and electrospray ionization mass spectrometry) of the novel compound 3 is mentioned too.
