The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were
investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The
results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg−1
) markedly promoted the
recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the
decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that
copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to
an increase of the activity of endogenous superoxide dismutase.