Metal-Based Drugs

Metal-Based Drugs / 2007 / Article

Research Article | Open Access

Volume 2007 |Article ID 067376 | https://doi.org/10.1155/2007/67376

G. Gencheva, D. Tsekova, G. Gochev, G. Momekov, G. Tyuliev, V. Skumryev, M. Karaivanova, P. R. Bontchev, "Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents", Metal-Based Drugs, vol. 2007, Article ID 067376, 13 pages, 2007. https://doi.org/10.1155/2007/67376

Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents

Academic Editor: Irena Kostova
Received09 Feb 2007
Accepted09 May 2007
Published07 Aug 2007

Abstract

Three novel stable Pt(III) complexes with distorted octahedral structure and (dz2)1 ground state have been obtained in the course of Pt(II)-hematoporphyrin IX ((7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H-23H-porphyn-2,18-dipropionic acid), Hp) interaction in alkaline aqueous medium and aerobic conditions. A redox interaction also takes place together with the complexation process leading to the formation of Pt(III) species and organic radicals. The processes in the reaction system and the structure of the complexes formed cis-[Pt(III)(NH3)2(Hp3H)(H2O)2]H2O1, [Pt(III)(Hp3H)(H2O)2]H2O2, and [Pt((O,O)Hp2H)Cl(H2O)3] 3, were studied by UV-Vis, IR, EPR and XPS spectra, thermal (TGS, DSC), potentiometric and magnetic methods. The newly synthesized complexes show promising cytotoxic activity comparable with that of cis-platin in in vitro tests against a panel of human leukemia cell lines. The observed cytotoxicity of the complex 2 against SKW-3 cells (KE-37 derivative) is due to induction of cell death through apoptosis.

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Copyright © 2007 G. Gencheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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