Table of Contents
Metal-Based Drugs
Volume 2008, Article ID 275084, 8 pages
http://dx.doi.org/10.1155/2008/275084
Research Article

DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Co(en)2(py)2]3+ and [Co(en)2(mepy)2]3+

1Department of chemistry, Faculty of Science, Osmania University, Hyderabad, Andhra Pradesh 500 007, India
2Indian Institute of Chemical Technology, Taranaka, Hyderabad 500 007, India

Received 7 May 2007; Accepted 4 July 2007

Academic Editor: Jannie C. Swarts

Copyright © 2008 Penumaka Nagababu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. E. Erkkila, D. T. Odom, and J. K. Barton, “Recognition and reaction of metallointercalators with DNA,” Chemical Reviews, vol. 99, no. 9, pp. 2777–2795, 1999. View at Publisher · View at Google Scholar
  2. M. Demeunynck, C. Bailly, and W. D. Wilson, Eds., DNA and RNA Binders: From Small Molecules to Drugs, M. Demeunynck, C. Bailly, and W. D. Wilson, Eds., Wiley-VCH, Weinheim, Germany, 2003.
  3. M. Gielen and E. R. T. Tiekink, Eds., Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine, M. Gielen and E. R. T. Tiekink, Eds., John Wiley & Sons, New York, NY, USA, 2005.
  4. J. A. Cowan, “Chemical nucleases,” Current Opinion in Chemical Biology, vol. 5, no. 6, pp. 634–642, 2001. View at Publisher · View at Google Scholar
  5. L.-N. Ji, X.-H. Zou, and J.-G. Liu, “Shape- and enantioselective interaction of Ru(II)/Co(III) polypyridyl complexes with DNA,” Coordination Chemistry Reviews, vol. 216-217, pp. 513–536, 2001. View at Publisher · View at Google Scholar
  6. J. K. Barton, “Metals and DNA: molecular left-handed complements,” Science, vol. 233, no. 4765, pp. 727–734, 1986. View at Publisher · View at Google Scholar
  7. C. S. Chow and J. K. Barton, “Shape-selective cleavage of tRNAPhe by transition-metal complexes,” Journal of the American Chemical Society, vol. 112, no. 7, pp. 2839–2841, 1990. View at Publisher · View at Google Scholar
  8. X. Qu and J. B. Chaires, “Hydration changes for DNA intercalation reactions,” Journal of the American Chemical Society, vol. 123, no. 1, pp. 1–7, 2001. View at Publisher · View at Google Scholar
  9. Y. Xiong and L.-N. Ji, “Synthesis, DNA-binding and DNA-mediated luminescence quenching of Ru(II) polypyridine complexes,” Coordination Chemistry Reviews, vol. 185-186, pp. 711–733, 1999. View at Publisher · View at Google Scholar
  10. J. K. Barton, “Tris (phenanthroline) metal complexes: probes for DNA helicity,” Journal of Biomolecular Structure & Dynamics, vol. 1, no. 3, pp. 621–632, 1983. View at Google Scholar
  11. J. K. Barton and A. L. Raphael, “Photoactivated stereospecific cleavage of double-helical DNA by cobalt(III) complexes,” Journal of the American Chemical Society, vol. 106, no. 8, pp. 2466–2468, 1984. View at Publisher · View at Google Scholar
  12. N. Farrell, L. R. Kelland, J. D. Roberts, and M. Van Beusichem, “Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action,” Cancer Research, vol. 52, no. 18, pp. 5065–5072, 1992. View at Google Scholar
  13. Y. Kageyama, Y. Yamazaki, and H. Okuno, “Novel approaches to prodrugs of anticancer diaminodichloroplatinum(II) complexes activated by stereoselective enzymatic ester hydrolysis,” Journal of Inorganic Biochemistry, vol. 70, no. 1, pp. 25–32, 1998. View at Publisher · View at Google Scholar
  14. H. Schonenberger, B. Wappes, M. Jennerwein, E. von Angerer, and J. Engel, “(1,2-diphenyl)-ethylenediamine-platinum (II) complex compounds,” 1986, US459809. View at Google Scholar
  15. F. Bernges and E. Holler, “Ring-substituted diaqua(1,2-diphenylethylenediamine)platinum(II) sulfate reacts with DNA through a dissociable complex,” European Journal of Biochemistry, vol. 208, no. 3, pp. 573–579, 1992. View at Publisher · View at Google Scholar
  16. T. Spruss, G. Bernhardt, E. Schickaneder, and H. Schönenberger, “Different response of murine and human mammary tumour models to a series of diastereoisomeric [1,2-bis(difluorophenyl) ethylenediamine]dichloroplatinum(II) complexes,” Journal of Cancer Research and Clinical Oncology, vol. 117, no. 5, pp. 435–443, 1991. View at Publisher · View at Google Scholar
  17. S. Schertl, R. W. Hartmann, C. Batzl-Hartmann et al., “[1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action II: contribution of drug inactivation, cellular drug uptake and sterical factors in the drug-target interaction to the antitumor activity,” Archiv der Pharmazie, vol. 337, no. 6, pp. 349–359, 2004. View at Publisher · View at Google Scholar · View at PubMed
  18. P. Nagababu, J. N. L. Latha, and S. Satyanarayana, “DNA-binding studies of mixed-ligand (ethylenediamine)ruthenium(II) complexes,” Chemistry & Biodiversity, vol. 3, no. 11, pp. 1219–1229, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. P. Nagababu and S. Satyanarayana, “DNA binding and cleavage properties of certain ethylenediamine cobalt(III) complexes of modified 1,10-phenanthrolines,” Polyhedron, vol. 26, no. 8, pp. 1686–1692, 2007. View at Publisher · View at Google Scholar
  20. P. Nagababu and S. Satyanarayana, “DNA binding and photocleavage studies of cobalt(III) polypyridine complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+,” Bioinorganic Chemistry and Applications , vol. 2007, Article ID 54562, p. 8 pages, 2007. View at Publisher · View at Google Scholar · View at PubMed
  21. P. Pallavi, P. Nagababu, and S. Satyanarayana, “Biomimetic model of coenzyme B12: aquabis(ethane-1,2-diamine-ΚN,ΚN)ethylcobalt(III) - its kinetic and binding studies with imidazoles and amino acids and interactions with CT DNA,” Helvetica Chimica Acta, vol. 90, no. 3, pp. 627–639, 2007. View at Publisher · View at Google Scholar
  22. B. P. Sullivan, D. J. Salmon, and T. J. Meyer, “Mixed phosphine 2,2-bipyridine complexes of ruthenium,” Inorganic Chemistry, vol. 17, no. 12, pp. 3334–3341, 1978. View at Publisher · View at Google Scholar
  23. J. Marmur, “A procedure for the isolation of DNA from microorganisms,” Journal of Molecular Biology, vol. 3, pp. 208–218, 1961. View at Google Scholar
  24. W. C. Fernelius, Ed., Inorganic Syntheses: Volume 2, W. C. Fernelius, Ed., McGraw-Hill, New York, NY, USA, 1946. View at Publisher · View at Google Scholar
  25. A. C. Barve, S. Ghosh, A. A. Kumbhar, A. S. Kumbhar, and V. G. Puranik, “DNA-binding studies of mixed ligand cobalt(III) complexes,” Transition Metal Chemistry, vol. 30, no. 3, pp. 312–316, 2005. View at Publisher · View at Google Scholar
  26. R. D. Gillard, R. E. E. Hill, and R. Maskill, “Optically active co-ordination compounds—part XX: reactions of 1,10-phenanthroline co-ordinated to cobalt(III),” Journal of the Chemical Society A, vol. 707, pp. 1447–1451, 1970. View at Publisher · View at Google Scholar
  27. A. M. Funston, R. W. Gable, W. D. McFadyen, and P. A. Tregloan, “The preparation of a mixed-ligand cobalt(III) complex of DPPZ and ethylenediamine: crystal structures of [Co(en)2(DPPZ)](CIO4)3.0.5H2O, [Co(en)2(bpy)]Br(CIO4)2 and [Co(en)2(phen)]Br3,” Australian Journal of Chemistry, vol. 52, no. 8, pp. 817–822, 1999. View at Publisher · View at Google Scholar
  28. D. M. Roundhill, Photochemistry and Photophysics of Metal Complexes, Plenum Press, New York, NY, USA, 1994.
  29. J. B. Chaires, N. Dattagupta, and D. M. Crothers, “Selfassociation of daunomycin,” Biochemistry, vol. 21, no. 17, pp. 3927–3932, 1982. View at Publisher · View at Google Scholar
  30. S. Satyanarayana, J. C. Dabrowiak, and J. B. Chaires, “Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: mode and specificity of binding,” Biochemistry, vol. 32, no. 10, pp. 2573–2584, 1993. View at Publisher · View at Google Scholar
  31. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Publisher · View at Google Scholar
  32. A. Wolfe, G. H. Shimer, Jr., and T. Meehan, “Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA,” Biochemistry, vol. 26, no. 20, pp. 6392–6396, 1987. View at Publisher · View at Google Scholar
  33. S. Satyanarayana, J. C. Dabrowiak, and J. B. Chaires, “Neither Δ- nor Λ-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation,” Biochemistry, vol. 31, no. 39, pp. 9319–9324, 1992. View at Google Scholar
  34. J. M. Kelly, A. B. Tossi, D. J. McConnell, and C. OhUigin, “A study of the interactions of some polypyridylruthenium(II) complexes with DNA using fluorescence spectroscopy, topoisomerisation and thermal denaturation,” Nucleic Acids Research, vol. 13, no. 17, pp. 6017–6034, 1985. View at Publisher · View at Google Scholar
  35. E. Tselepi-Kalouli and N. Katsaros, “The interaction of [Ru(NH3)5CI]2+ and [Ru(NH3)6]3+ ions with DNA,” Journal of Inorganic Biochemistry, vol. 37, no. 4, pp. 271–282, 1989. View at Publisher · View at Google Scholar
  36. R. B. López, B. L. Loeb, T. Boussie, and T. J. Meyer, “Synthesis of a new phenanthroline derived ligand with acceptor properties,” Tetrahedron Letters, vol. 37, no. 31, pp. 5437–5440, 1996. View at Publisher · View at Google Scholar
  37. D. R. Graham, L. E. Marshall, K. A. Reich, and D. S. Sigman, “Cleavage of DNA by coordination complexes. Superoxide formation in the oxidation of 1,10-phenanthroline-cuprous complexes by oxygen - relevance to DNA-cleavage reaction,” Journal of the American Chemical Society, vol. 102, no. 16, pp. 5419–5421, 1980. View at Publisher · View at Google Scholar
  38. J. K. Barton and A. L. Raphael, “Photoactivated stereospecific cleavage of double-helical DNA by cobalt(III) complexes,” Journal of the American Chemical Society, vol. 106, no. 8, pp. 2466–2468, 1984. View at Publisher · View at Google Scholar