Table of Contents
Metal-Based Drugs
Volume 2008 (2008), Article ID 384010, 7 pages
http://dx.doi.org/10.1155/2008/384010
Research Article

Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

1Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA
2Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA

Received 14 March 2008; Accepted 27 May 2008

Academic Editor: Alberta Bergamo

Copyright © 2008 Doug A. Medvetz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A class of Ag(I) N-heterocyclic carbene silver complexes, 13, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 13 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.