Metallocene Antimalarials: The Continuing Quest

Table 4

In vitro activity of coordination complexes and the free 4-aminoquinoline ligands in chloroquine-sensitive (D10) and chloroquine-resistant (K1) strains of P. falciparum.

Compound	D10 (CQ sensitive)	K1 (CQ resistant)
	IC50(nM)	IC50 (nM)
L1	37.10	570.0
[Au(L1)(PPh3)]NO3	21.09	61.53
[Au(C6F5)(L1)]	18.07	61.09
[Rh(Cl)(COD)(L1)]	21.50	81.31
L2	16.30	4.96
[Au(L2)(PPh3)]NO3	10.50	5.68
[Au(C6F5)(L2)]	10.08	3.96
[Rh(Cl)(COD)(L2)]	15.80	10.55
L3	11.30	12.56
[Au(L3)(PPh3)]NO3	33.27	33.89
[Au(C6F5)(L3)]	13.70	14.65
[Rh(Cl)(COD)(L3)]	202.00	597.59
L4	16.54	15.54
[Au(L4)(PPh3)]NO3	30.32	31.09
[Au(C6F5)(L4)]	23.36	12.92
[Rh(Cl)(COD)(L4)]	56.10	47.70