Table of Contents
Metal-Based Drugs
Volume 2008, Article ID 723634, 7 pages
http://dx.doi.org/10.1155/2008/723634
Research Article

Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2-Bipyridyl

1Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
2Liver Research Laboratory, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

Received 27 May 2007; Revised 30 October 2007; Accepted 13 February 2008

Academic Editor: Rafael Moreno-Sanchez

Copyright © 2008 Sahar I. Mostafa and Farid A. Badria. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. P. Hacker, E. B. Douple, and I. H. Krakoff, Platinium Coordination Complexes in Cancer Chemotherapy, Martinus Nijhoff, Dordrecht, The Netherlands, 1984.
  2. M. Coluccia, A. Nassi, F. Loseto et al., “A trans-platinum complex showing higher antitumor activity than the cis congeners,” Journal of Medicinal Chemistry, vol. 36, no. 4, 510 pages, 1993. View at Publisher · View at Google Scholar
  3. F. P. T. Harmers, W. H. Gispen, and J. P. Neijt, “Neurotoxic side-effects of cisplatin,” European Journal of Cancer, vol. 27, 372 pages, 1991. View at Google Scholar
  4. S. I. Mostafa, “Mixed ligand complexes with 2-piperidine-carboxylic acid as primary ligand and ethylene diamine, 2,2-bipyridyl, 1,10-phenanthroline and 2(2-pyridyl)quinoxaline as secondary ligands: preparation, characterization and biological activity,” Transition Metal Chemistry, vol. 32, no. 6, 769 pages, 2007. View at Publisher · View at Google Scholar
  5. S. I. Mostafa, “Synthesis, characterization and antineoplastic activity of 5-chloro-2,3-dihydroxypyridine transition metal complexes,” Journal of Coordination Chemistry, in press. View at Publisher · View at Google Scholar
  6. V. X. Jin and J. D. Ranford, “Complexes of platinum(II) or palladium(II) with 1,10-phenanthroline and amino acids,” Inorganica Chimica Acta, vol. 304, no. 1, 38 pages, 2000. View at Publisher · View at Google Scholar
  7. G. Cavigiolio, L. Benedetto, E. Boccaleri, D. Colangelo, H. Viano, and D. Osella, “Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase,” Inorganica Chimica Acta, vol. 305, no. 1, 61 pages, 2000. View at Publisher · View at Google Scholar
  8. S. K. Hadjikakou, M. A. Demertzis, M. Kubicki, and D. Kovala-Demertzis, “Organotin adducts with pyrimidinethione: crystal structure of dimethyldi(pyrimidine-2-thiolato)tin(IV) and diphenyldi(pyrimidine-2-thiolato)tin(IV),” Applied Organometallic Chemistry, vol. 14, no. 11, 727 pages, 2000. View at Publisher · View at Google Scholar
  9. V. N. Krishnamurthy, K. V. Naglowara Rao, P. L. Narasimha Rao, and B. Praphulla, “Some potential antiviral agents,” British Journal of Pharmacology and Chemotherapy, vol. 31, no. 1, 1 pages, 1967. View at Google Scholar
  10. M. D. Couce, G. Faraglia, U. Russo et al., “2-mercaptopyridine derivatives as neutral or ionic donors towards tin tetrahalides,” New Journal of Chemistry, vol. 21, no. 10, 1103 pages, 1997. View at Google Scholar
  11. S. D'Ancona, G. Magnolfi, G. Guidetti et al., “Effects of 6,6-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10),” Chemioterapia, vol. 5, no. 4, 219 pages, 1986. View at Google Scholar
  12. S. I. Mostafa and N. Hadjiliadis, “New biologically active transition metal complexes of 2-mercapto-4,6-diamino-5-hydroxypyrimidine,” Inorganic Chemistry: An Indian Journal, vol. 2, no. 3, 186 pages, 2007. View at Google Scholar
  13. W. P. Griffith and S. I. Mostafa, “Complexes of esculetin with second and third row transition elements,” Polyhedron, vol. 11, no. 8, 871 pages, 1992. View at Publisher · View at Google Scholar
  14. K. R. Sheeji, G. Kuttan, and R. Kuttan, Amala Research Bulletin, vol. 17, 73 pages, 1997.
  15. W. J. Geary, Coordination Chemistry Reviews, vol. 7, no. 81, 1981.
  16. A. Abdullah, F. Huq, A. Chowdhury, H. Tayyem, P. Beale, and K. Fisher, “Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the formml: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine,” BMC Chemical Biology, vol. 6, article 3, 1472 pages, 2006. View at Publisher · View at Google Scholar · View at PubMed
  17. Z. Popovic, D. M. Calogovic, J. Hasic, and D. V. Topic, “Preparation and spectroscopic properties of the complexes of mercuric thiocyanate with pyridine-2-thione and pyridine-2-carboxylic acid. Crystal and molecular structure of two polymorphs of Hg(SCN)2(C5H5NS)2,” Inorganica Chimica Acta, vol. 285, no. 2, 208 pages, 1999. View at Publisher · View at Google Scholar
  18. M. D. Gutierrez, R. Lopez, M. A. Romero, and J. M. Salas, “Spectroscopic studies of some Pd(II), Pt(II), Ag(I), and Au(III) complexes of 4,6-diamino-2-thiopyrimidine and 4,6-diamino-2-methylthiopyrimidine. Structure and binding site determination,” Canadian Journal Chemistry, vol. 66, no. 2, 249 pages, 1988. View at Publisher · View at Google Scholar
  19. E. L. Torres and M. A. Mendiola, “Complexes of a triazine-3-thione ligand with divalent metals crystal structure of [CdL2DMF2]2 · 2DMF · 1/4H2O,” Polyhedron, vol. 24, no. 12, 1435 pages, 2005. View at Publisher · View at Google Scholar
  20. G. Glolub, H. Cohen, P. Paoletti, A. Bencini, and D. Meyerstein, “Copper-(I) and -(II) complexes with tertiary linear polyamines of the type Me2NCH2(CH2NMeCH2)nCH2NMe2(n=14),” Journal of the Chemical Society, Dalton Transactions, no. 10, 2055 pages, 1996. View at Publisher · View at Google Scholar
  21. S. I. Mostafa and S. A. Abd El-Maksoud, “Synthesis and characterization of some transition metal complexes of 2-amino-3-hydroxypyridine and its application in corrosion inhibition,” Monatshefte für Chemie, vol. 129, no. 5, 455 pages, 1998. View at Publisher · View at Google Scholar
  22. M. Guta and M. N. Srivastava, “Synthesis and characterization of complexes of copper(II), nickel(II), cobalt(II) and zinc(II) with alanine and uracil or 2-thiouracil,” Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, vol. 26, no. 2, 305 pages, 1996. View at Publisher · View at Google Scholar
  23. S. I. Mostafa, M. A. Kabil, E. M. Saad, and A. A. El-Asmy, “Ligational and analytical applications of a uracil derivative toward some transition metal ions,” Journal of Coordination Chemistry, vol. 59, no. 3, 279 pages, 2006. View at Publisher · View at Google Scholar
  24. C.-L. Ma, Y. Shi, Q.-F. Zhang, and Q. Jiang, “Syntheses, characterization and crystal structures of diorganotin compounds with 2-mercaptopyrimidine and 4-amino-2-mercaptopyrimidine,” Polyhedron, vol. 24, no. 10, 1109 pages, 2005. View at Publisher · View at Google Scholar
  25. R. Castro, J. A. G. Vazquez, J. Romero, A. Sousa, R. Pritchard, and C. A. McAuliffe, “4,6-dimethylpyrimidine-2-thionato (dmpymt) complexes of nickel(II) and cadmium(II). Crystal structure of [Cd(dmpymt)2]: a compound with a calixarene-like structure,” Journal of the Chemical Society, Dalton Transactions, no. 7, 1115 pages, 1994. View at Publisher · View at Google Scholar
  26. M. A. Haj, M. Quiros, J. M. Salas, and R. Faure, “Silver complexes with triazolopyrimidine ligands containing an exocyclic oxygen atomml: X-ray evidence for an unusual tautomeric form,” Journal of the Chemical Society, Dalton Transactions, no. 11, 1798 pages, 2001. View at Publisher · View at Google Scholar
  27. S. I. Mostafa and M. M. Bekheit, “Synthesis and structure studies of complexes of some second row transition metals with 1-(phenylacetyl and phenoxyacetyl)-4-phenyl-3- thiosemicarbazide,” Chemical and Pharmaceutical Bulletin, vol. 48, no. 2, 266 pages, 2000. View at Google Scholar
  28. F. Sabin, C. K. Ryu, P. Fork, and A. Vogler, “Photophysical properties of hexanuclear copper(I) and silver(I) clusters,” Inorganic Chemistry, vol. 31, no. 10, 1941 pages, 1992. View at Publisher · View at Google Scholar
  29. M. A. Omary, T. R. Webb, Z. Assefa, G. E. Shankle, and H. H. Patterson, “Crystal structure, electronic structure, and temperature-dependent Raman spectra of Tl[Ag(CN)2]: evidence for ligand-unsupported argentophilic interactions,” Inorganic Chemistry, vol. 37, no. 6, 1380 pages, 1998. View at Publisher · View at Google Scholar
  30. M. Calvo, A. M. Lanfredi, L. Oro et al., “Synthesis and properties of rhodium(I) chloranilate and 2,5-dihydroxy-1,4-benzoquinonate complexes. Crystal structures of the binuclear [Rh2(μ-CA) (cod)2] and tetranuclear [Rh4(μ-CA)2(cod)4] complexes (CA = cbloranilate anion),” Inorganic Chemistry, vol. 32, no. 7, 1147 pages, 1993. View at Publisher · View at Google Scholar
  31. W. P. Griffith and S. I. Mostafa, “Complexes of 3-hydroxypyridin-2-one and 1,2-dimethyl-3-hydroxypyridin-4-one with second and third row elements of groups 6, 7 and 8,” Polyhedron, vol. 11, no. 23, 2997 pages, 1992. View at Publisher · View at Google Scholar
  32. D. Aguado, T. Montoya, J. Ferrer, and A. Seco, “Relating ions concentration variations to conductivity variations in a sequencing batch reactor operated for enhanced biological phosphorus removal,” Environmental Modelling & Software, vol. 21, no. 6, 845 pages, 2006. View at Publisher · View at Google Scholar
  33. G. W. Castellan, Physical Chemistry, edited by L. Rogers, The Benjamin, Menlo Park, Calif, USA, 1983.
  34. B. D. Clarkson and J. H. Burchenal, “Preliminary screening of antineoplastic drugs,” Progress in Clinical Cancer, vol. 1, 625 pages, 1965. View at Google Scholar
  35. C. Oberling and M. Guerin, “The role of viruses in the production of cancer,” Advances in Cancer Research, vol. 2, 353 pages, 1954. View at Publisher · View at Google Scholar
  36. B. Ardalan, M. D. Buscagila, and P. S. Schein, “Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response,” Biochemical Pharmacology, vol. 27, no. 16, 2009 pages, 1978. View at Publisher · View at Google Scholar
  37. K. Yoshisue, Z. Hironaga, S. Yamaguchi, A. Yamamoto, S. Nagayama, and Y. Kawaguchi, “Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats,” Cancer Chemotherapy and Pharmacology, vol. 46, no. 1, 51 pages, 2000. View at Publisher · View at Google Scholar
  38. A. Romerosa, P. Bergamini, V. Bertolasi et al., “Biologically active platinum complexes containing 8-thiotheophylline and 8-(methylthio)theophylline,” Inorganic Chemistry, vol. 43, no. 3, 905 pages, 2004. View at Publisher · View at Google Scholar · View at PubMed
  39. D. Lebwohl and R. Canerra, “Clinical development of platinum complexes in cancer therapy: an historical perspective and an update,” European Journal of Cancer, vol. 34, no. 10, 1522 pages, 1998. View at Publisher · View at Google Scholar
  40. S. Osinsky, December 1998, Ukr Patent, Appl., no. 981 27 052.
  41. S. Osinsky, I. Levitin, L. Bubnovskaya et al., in Proceedings of the 6th Internet World Congress for Biomedical Sciences (INABIS '00), p. 1, Ciudad Real, Spain, February 2000.
  42. P. Sur and D. K. Ganguly, “Tea plant root extract (TRE) as an antineoplastic agent,” Planta Medica, vol. 60, 106 pages, 1994. View at Publisher · View at Google Scholar