Table of Contents
Metal-Based Drugs
Volume 2008, Article ID 875410, 7 pages
Research Article

Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes

Department of Chemistry, Dr. Harisingh Gour University, Sagar (M.P.) 470003, India

Received 12 November 2007; Revised 1 March 2008; Accepted 9 April 2008

Academic Editor: S. Liu

Copyright © 2008 A. P. Mishra and Monika Soni. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands.