Metal-Based Drugs

Metal-Based Drugs / 2009 / Article / Tab 2

Research Article

In Vitro Evaluation of Oxoplatin: An Oral Platinum(IV) Anticancer Agent

Table 2

Selected genes exhibiting fourfold commonly downregulated expression in H526 cells treated with oxoplatin or cisplatin compared to untreated control cells classified according to their cellular function. For gene expression analysis H526 SCLC cells were treated with 3.75  M oxoplatin or 4.1  M cisplatin, respectively, in tissue culture flasks for three days. Thereafter, RNA of control and treated cells was extracted, and gene expression was analyzed using Applied Biosystems Human Genome Survey Microarray V2.0.

Cellular processLocus linkGene symbolGene name

Transcription4150 MAZMYC-associated zinc finger protein (purine-binding transcription factor)
3221HOXC4Homeo box C4
10658CUGBP1CUG triplet repeat, RNA binding protein 1

Apoptosis8771TNFRSF6B Tumor necrosis factor receptor superfamily, member 6b, decoy
598BCL2L1BCL2-like 1
3855KRT7 Keratin 7

Cytoskeleton347733 MGC8685 Tubulin, beta polypeptide paralog
823 CAPN1 Calpain 1, (mu/I) large subunit
50861 STMN3 Stathmin-like 3
5962 RDXRadixin
977 CD151 CD151 antigen
50512 PODLX2 Endoglycan
55920 TD-60 RCC1-like
91179 SCARF2 Scavenger receptor class F, member 2
6711 SPTBN1 Spectrin, beta, nonerythrocytic 1
6596SMARCA3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
4134 MAP4Microtubule-associated protein 4

Signal transduction51582OAZINOrnithine decarboxylase antizyme inhibitor
26469PTPN18 Protein tyrosine phosphatase, nonreceptor type 18 (brain-derived)
11247NXPH4Neurexophilin 4
53944CSNK1G1Casein kinase 1, gamma 1
1445 CSKC-src tyrosine kinase
30851TIP-1Tax interaction protein 1
23187PHLDB1Pleckstrin homology-like domain, family B, member 1
3597IL13RA1Interleukin 13 receptor, alpha 1

Metabolism2539G6PDGlucose-6-phosphate dehydrogenase
5211PFKLPhosphofructokinase, liver
2542SLC37A4Solute carrier family 37 (glycerol-6-phosphate transporter), member 4
478 ATP1A3ATPase, Na+/K+ transporting, alpha 3 polypeptide
55611OTUB1OTU domain, ubiquitin aldehyde binding 1
2030SLC29A1Solute carrier family 29 (nucleoside transporters), member 1
6566SLC16A1solute carrier family 16 (monocarboxylic acid transporters), member 1

Transport29924EPN1Epsin 1
6844VAMP2Vesicle-associated membrane protein 2 (synaptobrevin 2)
10527IPO7Importin 7
7514XPO1 Exportin 1 (CRM1 homolog, yeast)
1654DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

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