Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion
Effect on ability of cells to readhere after KP418 and KP1019 treatment. MDA-MB-231, MCF-7, and HBL-100 cells were treated for 1 hour with KP418 and KP1019 M, then the cells were removed from the flasks, collected, resuspended and seeded on 96-well plastic plates previously coated with poly-L-lysine, fibronectin, collagen IV and Matrigel. After 30 and 60 minutes of incubation cells that adhered to the substrates were detected by the SRB test. Data are the percent of variation versus controls calculated from the mean S.D. of two experiments, each performed in triplicate. , versus controls, ANOVA, and Tukey-Kramer post test.
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