Research Article

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion

Figure 5

Effect of KP418 and KP1019 on invasion of cells through Matrigel. MDA-MB-231, MCF-7, and HBL-100 cells were treated for 1 hour with KP418, KP1019  M, and KP1019# (# is equal to  M for MDA-MB-231 and MCF-7 and to  M for HBL-100), then the cells were removed from the flasks, collected, resuspended and seeded on inserts. Data represent cells that after 96 hours have invaded and are present on the lower surface of the filter. Data are the percent of variation versus controls calculated from the mean S.D. of two experiments, each performed in triplicate, : : : versus controls, ANOVA, and Tukey-Kramer post test.