Metal-Based Drugs
Volume 2010 (2010), Article ID 286298, 6 pages
http://dx.doi.org/10.1155/2010/286298
Cytotoxic Properties of Titanocenyl Amides on Breast Cancer Cell Line MCF-7
Department of Chemistry, University of Puerto Rico, P.O. Box 9019, Mayagüez, PR 00681, USA
Received 18 November 2009; Accepted 16 February 2010
Academic Editor: Alberta Bergamo
Copyright © 2010 Li Ming Gao and Enrique Meléndez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with