Table of Contents 
Metal-Based Drugs
Volume 2010 (2010), Article ID 286298, 6 pages
http://dx.doi.org/10.1155/2010/286298
Research Article

Cytotoxic Properties of Titanocenyl Amides on Breast Cancer Cell Line MCF-7

Li Ming Gao and Enrique Meléndez

Department of Chemistry, University of Puerto Rico, P.O. Box 9019, Mayagüez, PR 00681, USA

Received 18 November 2009; Accepted 16 February 2010

Academic Editor: Alberta Bergamo

Copyright © 2010 Li Ming Gao and Enrique Meléndez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with IC50<100 μM and IC50>100 μM. The most cytotoxic species is Cp(CpCO-NH-C6H4-(CH2)2CH3)TiCl2 with an IC50 of 24(2) μM, followed by Cp(CpCO-NH-C6H4-Br)TiCl2, IC50 of 46(4) μM and Cp(CpCO-NH-C6H4-OCF3)TiCl2, IC50 of 49(6) μM. There is no correlation between the nature of the para substituent on the phenyl ring and the cytotoxic properties on MCF-7 cell line.