new platinum complex ptcl acac 1 acac acac 2 dms contain singl chelat acac 1 one chelat one bond acac acetylaceton 2 have been synthes the new complex exhibit high vitro cytotox cisplatin sensit resist cell line show neglig reactiv nucleobas guo 5 gmp select substitut dmso dms soft biolog nucleophil lmethionin order assess abil new complex respect cisplatin induc apoptosi interact nongenom target ames test standard revers mutat assay carri out two salmonella typhimurium strain ta98 ta100 interest new complex did show wellknown mutagen activ exhibit cisplatin therefor abl activ apoptot pathway without interact dna

Sandra Angelica De Pascali

Federica Lugoli

Antonella De Donno

Francesco Paolo Fanizzi

Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets

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Table of Contents: 2011

Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets