Glycolysis in the African Trypanosome: Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development

Figure 2

PTS binding proteins participate in delivery of glycolytic enzymes to the glycosome. Fully folded PTS2 harboring proteins expressed in the cytoplasm, like the TbHKs, are targeted to the glycosome through the binding of PEX7 to the PTS2. This complex may or may not interact with PEX5 prior to delivery to PEX14 for transfer to the glycosome matrix. PFK, which harbors an internal PTS1 targeting sequence, is targeted by PEX5.