Review Article
Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer
Table 1
Clinical diagnostic criteria for HNPCC.
| Amsterdam minimum criteria (1990) |
| (1) At least 3 cases of colorectal cancer in relatives (verified pathologically) | (2) One is a first degree relative of the other two | (3) At least two successive generations should be affected | (4) One case of colorectal cancer diagnosed before the age of 50 years old | (5) FAP should be excluded |
| Revised amsterdam criteria II (1998) |
| (1) At least 3 relatives with an HNPCC-associated cancer (cancer of the colorectum, endometrium, small bowel, ureter or renal pelvis) | (2–5) As for the minimum criteria |
|
|