Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones

Table 1

IC₅₀ values/1 d (μM) for the effect of N1, N2, and N3 against T. cruzi ^a.

	Trypomastigotes		Epimastigotes	Amastigotes
	0% blood	100% blood		Extracellular^b	Intracellular^c
N1	35.8 ± 1.2^d	62.1 ± 3.0	82.8 ± 7.4	13.4 ± 1.1	9.0 ± 2.9
N2	12.3 ± 1.2	61.6 ± 3.6	36.0 ± 1.9	12.4 ± 1.9	6.5 ± 1.0
N3	28.2 ± 0.9	68.3 ± 7.3	30.7 ± 3.6	9.7 ± 0.2	7.2 ± 0.2

^aReferences [123, 124].
^bTissue-cultured derived amastigotes.
^cNumber of amastigotes/100 peritoneal macrophages.
^dMean ± SD of at least 3 independent experiments.