Use of Antimony in the Treatment of Leishmaniasis: Current Status and Future Directions

Table 1

Changing therapeutic response to pentavalent antimonials (Adapted from T. K. Jha, 2006 [219]).

Study	Dose (mg/kg/day)	Duration (days)	No. of courses	No. of cases	Unresponsiveness (%)
Jha, (1980) [220]	10	10	1	200	17
Thakur et al., (1984) [221]	20	20	1	64	8
		>20	1	62	0
Jha, (1986) [222]	Child-20	Fresh-30	1	Fresh-73	1.1
	Adult-10	Relapse-60	1	Relapse-17
		Slow	1
		response-42
Thakur et al., (1988) [223]	10	40	1	371	26
	15		1		14
	20		1		3
Jha, (1992) [224]	20	30	1	252	27.1
Jha, (1995) [225]	20	30	1	32	25
Jha, (1998) [226]	20	30	1	30	37
Thakur et al., (1998) [227]	20	30	1	80	54
Sundar et al., (2001) [102]	20	30	1	184	60