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Molecular Biology International
Volume 2011 (2011), Article ID 594529, 13 pages
Review Article

Copper and Its Complexes in Medicine: A Biochemical Approach

1Department of Physics Chemistry & Materials Technology, Technological Educational Institute of Athens, 12210 Athens, Greece
2Biology Unit, Department of Pre-School Education, University of Thessaly, Argonafton and Filellinon Streets, Volos 38221, Greece

Received 27 February 2011; Accepted 10 April 2011

Academic Editor: Dimitrios Morikis

Copyright © 2011 Isidoros Iakovidis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of a novel generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to summarize all the available-to-date information on these issues.