Structure and Function of the Small MutS-Related Domain

Table 1

Distribution of Smr domain-containing proteins.

Species	Proteins containing family 1 Smr domains	Proteins containing family 2 Smr domains	Proteins containing family 3 Smr domains
Thermus thermophilus	MutS2 (YP_144911)^*1	—	—
Helicobacter pylori	MutS2 (ZP_03440043)	—	—
Bacillus subtilis	MutS2 (NP_390736)	—	—
Deinococcus radiodurans	MutS2 (NP_295699)	—	—
Aquifex aeolicus	MutS2 (NP_213851)	—	—
Thermotoga maritima	MutS2 (NP_229083)	—	—
Arabidopsis thaliana	MutS2 (NP_200220)	GUN1 (NP_849962)	—
		pTAC2 (NP_177623)
		SVR7 (Q8GWE0.2)
		At5G46580 (NP_199470)
		At1G79490 (NP_178067)
		At1G18900 (NP_973860)
		At1G74750 (NP_177613)
		At2G17033 (NP_849962)
Escherichia coli	—	—	YdaL (NP_415856)^*5
			YfcN (AP_002931)
Neisseria gonorrhoeae	—	—	NGO0880 (YP_207992)
Pseudomonas aeruginosa	—	—	Hypothetical protein (AAG_05064)
Saccharomyces cerevisiae	—	CUE2 protein (EEU_05137)	—
		Ypl199cp (NP_015125)^*2
Caenorhabditis elegans	—	Hypothetical protein (NP_498004)	Hypothetical protein (NP_494494)
			Hypothetical protein (NP_494390)
Drosophila melanogaster	—	CG7139, isoform A (NP_649378)^*3	—
Mus musculus	—	N4BP2 (NP_001020088)^*4	—
Homo sapiens	—	N4BP2 (NP_060647)	—

^*1Numbers in parenthesis indicate accession numbers.
^*2Ypl199cp also contains DUF1771.
^*3CG7139 shows amino acid sequence similarity to mammalian N4BP2-like proteins. The highly conserved domain, DUF1771, is adjacent to the Smr domain in CG7139.
^*4DUF1771 is adjacent to the Smr domains in mammalian N4BP2.
^*5Organisms that possess a family 3 Smr domain do not have a family 1 Smr domain [11].