Table of Contents
Molecular Biology International
Volume 2011, Article ID 782971, 9 pages
http://dx.doi.org/10.4061/2011/782971
Review Article

Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani

1Molecular Cell Biology Laboratory, Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata 700032, India
2Department of Biotechnology, Presidency College, Kolkata 700073, India

Received 31 January 2011; Accepted 1 April 2011

Academic Editor: Hemanta K. Majumder

Copyright © 2011 Arunima Biswas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Saar, A. Ransford, E. Waldman et al., “Characterization of developmentally-regulated activities in axenic amastigotes of Leishmania donovani,” Molecular and Biochemical Parasitology, vol. 95, no. 1, pp. 9–20, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Ephros, E. Waldman, and D. Zilberstein, “Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes,” Antimicrobial Agents and Chemotherapy, vol. 41, no. 5, pp. 1064–1068, 1997. View at Google Scholar · View at Scopus
  3. J. H. Zarley, B. E. Britigan, and M. E. Wilson, “Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes: role of hydroxyl radical and protection by heat shock,” Journal of Clinical Investigation, vol. 88, no. 5, pp. 1511–1521, 1991. View at Google Scholar · View at Scopus
  4. K. R. Gantt, T. L. Goldman, M. L. McCormick et al., “Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi,” Journal of Immunology, vol. 167, no. 2, pp. 893–901, 2001. View at Google Scholar · View at Scopus
  5. R. D. Pearson, J. L. Harcus, D. Roberts, and G. R. Donowitz, “Differential survival of Leishmania donovani amastigotes in human monocytes,” Journal of Immunology, vol. 131, no. 4, pp. 1994–1999, 1983. View at Google Scholar · View at Scopus
  6. S. D. Barr and L. Gedamu, “Cloning and characterization of three differentially expressed peroxidoxin genes from Leishmania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals,” Journal of Biological Chemistry, vol. 276, no. 36, pp. 34279–34287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Tovar, M. L. Cunningham, A. C. Smith, S. L. Croft, and A. H. Fairlamb, “Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 9, pp. 5311–5316, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Tovar, S. Wilkinson, J. C. Mottram, and A. H. Fairlamb, “Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus,” Molecular Microbiology, vol. 29, no. 2, pp. 653–660, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Ghosh, S. Goswami, and S. Adhya, “Role of superoxide dismutase in survival of Leishmania within the macrophage,” Biochemical Journal, vol. 369, no. 3, pp. 447–452, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. K. A. Plewes, S. D. Barr, and L. Gedamu, “Iron superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival,” Infection and Immunity, vol. 71, no. 10, pp. 5910–5920, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. A. Miller, S. E. McGowan, K. R. Gantt et al., “Inducible resistance to oxidant stress in the protozoan Leishmania chagasi,” Journal of Biological Chemistry, vol. 275, no. 43, pp. 33883–33889, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. D. C. Kaushal, R. Carter, L. H. Miller, and G. Krishna, “Gametocytogenesis by malaria parasites in continuous culture,” Nature, vol. 286, no. 5772, pp. 490–492, 1980. View at Google Scholar · View at Scopus
  13. S. Egée, F. Lapaix, G. Decherf et al., “A stretch-activated anion channel is up-regulated by the malaria parasite Plasmodium falciparum,” Journal of Physiology, vol. 542, no. 3, pp. 795–801, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Merckx, M. P. Nivez, G. Bouyer et al., “Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance,” PLoS Pathogens, vol. 4, article e19, no. 2, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. E. Mancini and C. L. Patton, “Cyclic 3',5'-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat,” Molecular and Biochemical Parasitology, vol. 3, no. 1, pp. 19–31, 1981. View at Google Scholar · View at Scopus
  16. A. Smith, M. P. Ward, and S. Garrett, “Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation,” EMBO Journal, vol. 17, no. 13, pp. 3556–3564, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. S. B. Ferguson, E. S. Anderson, R. B. Harshaw, T. Thate, N. L. Craig, and H. C. M. Nelson, “Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae,” Genetics, vol. 169, no. 3, pp. 1203–1214, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Seebeck, R. Schaub, and A. Johner, “cAMP signalling in the kinetoplastid protozoa,” Current Molecular Medicine, vol. 4, no. 6, pp. 585–599, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Bhattacharya, A. Biswas, and P. K. Das, “Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmania donovani,” Free Radical Biology and Medicine, vol. 44, no. 5, pp. 779–794, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Barak, S. Amin-Spector, E. Gerliak, S. Goyard, N. Holland, and D. Zilberstein, “Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response,” Molecular and Biochemical Parasitology, vol. 141, no. 1, pp. 99–108, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Sanchez, D. Zeoli, E. M. Klamo, M. P. Kavanaugh, and S. M. Landfear, “A family of putative receptor-adenylate cyclases from Leishmania donovani,” Journal of Biological Chemistry, vol. 270, no. 29, pp. 17551–17558, 1995. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Besteiro, D. Tonn, L. Tetley, G. H. Coombs, and J. C. Mottram, “The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania,” Journal of Cell Science, vol. 121, part 5, pp. 561–570, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Johner, S. Kunz, M. Linder, Y. Shakur, and T. Seebeck, “Cyclic nucleotide specific phosphodiesterases of Leishmania major,” BMC Microbiology, vol. 6, article 25, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Bhattacharya, A. Biswas, and P. K. Das, “Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani,” Free Radical Biology and Medicine, vol. 47, no. 10, pp. 1494–1506, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. M. Siman-Tov, R. Aly, M. Shapira, and C. L. Jaffe, “Cloning from Leishmania major of a developmentally regulated gene, c-lpk2, for the catalytic subunit of the cAMP-dependent protein kinase,” Molecular and Biochemical Parasitology, vol. 77, no. 2, pp. 201–215, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. M. M. Siman-Tov, A. C. Ivens, and C. L. Jaffe, “Molecular cloning and characterization of two new isoforms of the protein kinase A catalytic subunit from the human parasite Leishmania,” Gene, vol. 288, no. 1-2, pp. 65–75, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. M. G. Gold, B. Lygren, P. Dokurno et al., “Molecular basis of AKAP specificity for PKA regulatory subunits,” Molecular Cell, vol. 24, no. 3, pp. 383–395, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Huang, L. M. Weiss, F. Nagajyothi, H. B. Tanowitz, and M. Wittner, “Molecular cloning and characterization of the protein kinase A regulatory subunit of Trypanosoma cruzi,” Molecular and Biochemical Parasitology, vol. 149, no. 2, pp. 242–245, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Bhattacharya, A. Biswas, and P. K. Das, “Involvement of a protein kinase A regulatory subunit from Leishmania in metacyclogenesis through induction of autophagy,” Communicated.
  30. M. Mavrakis, J. Lippincott-Schwartz, C. A. Stratakis, and I. Bossis, “Depletion of type IA regulatory subunit (RIα) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency,” Human Molecular Genetics, vol. 15, no. 19, pp. 2962–2971, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Mavrakis, J. Lippincott-Schwartz, C. A. Stratakis, and I. Bossis, “mTOR kinase and the regulatory subunit of protein kinase A (PRKAR1A) spatially and functionally interact during autophagosome maturation,” Autophagy, vol. 3, no. 2, pp. 151–153, 2007. View at Google Scholar · View at Scopus
  32. T. Schmelzle, T. Beck, D. E. Martin, and M. N. Hall, “Activation of the RAS/Cyclic AMP pathway suppresses a TOR deficiency in yeast,” Molecular and Cellular Biology, vol. 24, no. 1, pp. 338–351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. P. A. Thomason, D. Traynor, G. Cavet, W. T. Chang, A. J. Harwood, and R. R. Kay, “An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium,” EMBO Journal, vol. 17, no. 10, pp. 2838–2845, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Dürrenberger, K. Wong, and J. W. Kronstad, “Identification of a cAMP-dependent protein kinase catalytic subunit required for virulence and morphogenesis in Ustilago maydis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 10, pp. 5684–5689, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Besteiro, R. A. Williams, L. S. Morrison, G. H. Coombs, and J. C. Mottram, “Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major,” Journal of Biological Chemistry, vol. 281, no. 16, pp. 11384–11396, 2006. View at Publisher · View at Google Scholar · View at Scopus