Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum

Table 1

Contacts between the peptide WRWYCRCK, and the noncovalent pfTopoI-DNA complex calculated for the best docked complex.

Peptide	Protein	DNA
Trp1	—	—
Arg2	Lys208, Gly313, Glu314, Ser514	Ade13
Trp3	Tyr205, Lys208, Arg310, Arg312, Gly313	Ade14
Tyr4	Arg312, Gly313, Asp513	Gua12, Ade13, Ade14
Cys5	Tyr205, Arg310, Gly311	Ade14
Arg6	Arg312	Gua12, Ade13, Ade14, Ade15, Thy32, Cyt33
Cys7	Lys322	—
Lys8	—	Ade15, Cyt33, Thy34