Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis

Table 3

IL-1A C[−889]T allele frequency, genotype distribution, and HWE status in the cases and controls.

Parameter	Overall 𝑁=80	Cases 𝑛=40	Controls 𝑛=40	OR^¶ (95% CI)
				Dominant model	Additive model	Recessive model
C allele	85 (53.1%)	36 (45.0%)	49 (61.2%)		—^a
T allele	75 (46.9%)	44 (55.0%)	31 (38.8%)		1.92 (0.86–4.27)^b
CC genotype	21 (26.3%)	08 (20.0%)	13 (32.5%)
TC genotype	43 (53.7%)	20 (50.0%)	23 (57.5%)	1.43 (0.37–5.55)	2.18 (0.89–5.39)	6.29 (1.21–32.6)^*
TT genotype	16 (20.0%)	12 (30.0%)	04 (10.0%)
HWE^c	+	+	+		N/A

^¶OR: odds ratio in the cases compared to the controls; logistic regression adjusting for mean plaque index.
^aReference category.
^bModels are not applicable.
^cHWE: Hardy-Weinberg equilibrium; (+): consistent with; (−): significant deviation.
^*𝑃≤0.05.