The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents

<table>Potential impact of levels/ratios of dNTP : rNTP in macrophages upon emergence of mutagenic HIV-1. Similar ratios of dNTP : rNTP (point 1) confer preferential incorporation of rNTP and rNMP into the growing viral DNA strand (point 2).  Together, with suboptimal levels of repair machinery found in macrophages, these incorporations are a known correlate for production of mutagenic HIV-1 (point 3).</table>

Molecular Biology International

fig2

Figure 2

Figure 2: The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents 