Review Article

The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents

Table 1

Concentrations of dCTP, dGTP, dATP, TTP, and dUTP in activated or resting primary human macrophages versus lymphocytes. Concentrations of dNTPs are 6–133-fold lower in macrophages versus lymphocytes, independent of activation state [18, 25]. ±indicates standard deviation. Data represents at least five independent experiments performed with pooled cells from six independent donors.

dCTPdGTPdATPTTPdUTP

Activated lymphocytes

Activated macrophages

Fold difference between activated lymphocytes versus activated macrophages2530921076

Resting lymphocytes

Resting macrophages

Fold difference between resting lymphocytes versus resting macrophages6413133588