Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy

Figure 1

RASSF2 and K-Ras form an endogenous complex. Lysates from H441 and H1299 lung cancer cells were immunoprecipitated with a pan Ras antibody, fractionated on SDS gels, and immunoblotted with an anti-RASSF2 antibody. The endogenous interaction between Ras and RASSF2 was confirmed by the presence of RASSF2 in the proteins precipitated from the H441 cells but not the RASSF2-negative H1299 cells.