Research Article

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis

Figure 4

Caspase 3/7 activation was assessed in breast T47D (a) and lung H1299 (b) cancer cells overexpressing RASSF1A or RASSF1C after TNF-α treatment for 24 hr. Overexpression of RASSF1C significantly reduced caspase 3/7 activation in both breast and lung cancer cells. Data is representative of at least 3 independent experiments and the values represent the mean ± SEM. * for 1C compared to 1A and BB and for 1A compared to BB.