Table of Contents
Molecular Biology International
Volume 2015, Article ID 238586, 11 pages
http://dx.doi.org/10.1155/2015/238586
Review Article

Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas

1Clinic of Anesthesia and Intensive Care, Emergency County Hospital “Pius Brinzeu”, 300736 Timisoara, Romania
2Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
3Faculty of Chemistry, Biology, Geography, West University of Timisoara, 300115 Timisoara, Romania
4Clinic of Anesthesia and Intensive Care “Casa Austria”, Emergency County Hospital “Pius Brinzeu”, 300736 Timisoara, Romania

Received 7 August 2015; Accepted 15 October 2015

Academic Editor: Sharad S. Singhal

Copyright © 2015 Marius Papurica et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The critically ill polytrauma patient is a constant challenge for the trauma team due to the complexity of the complications presented. Intense inflammatory response and infections, as well as multiple organ dysfunctions, significantly increase the rate of morbidity and mortality in these patients. Moreover, due to the physiological and biochemical imbalances present in this type of patients, the bioproduction of free radicals is significantly accelerated, thus installing the oxidative stress. In the therapeutic management of such patients, multiple surgical interventions are required and therefore they are being subjected to repeated general anesthesia. In this paper, we want to present the pathophysiological implications of oxidative stress in critically ill patients with multiple traumas and the implications of general anesthesia on the redox mechanisms of the cell. We also want to summarize the antioxidant treatments able to reduce the intensity of oxidative stress by modulating the biochemical activity of some cellular mechanisms.