Molecular Biology International

DNA in 3R: Repair, Replication, and Recombination


Publishing date
15 Aug 2011
Status
Published
Submission deadline
15 Feb 2011

Lead Editor

1Group of Genome Expression and Repair, IGBMC, 67404 Illkirch Cedex, CU Strasbourg, France

2Group of Molecular Biology of B Cells, IGBMC, 67404 Illkirch Cedex, CU Strasbourg, France

3Group of Transcription and DNA Repair, IPBS, 205 route de Narbonne, 31077 Toulouse, France

4Department of Dermatology, Eberhard Karls University, 72076 Tuebingen, Germany


DNA in 3R: Repair, Replication, and Recombination

Description

DNA is continuously exposed to a range of damaging agents, including reactive cellular metabolites, environmental chemicals, ionizing radiation, and UV light. The biochemical consequences of DNA lesions are diverse and range from obstruction of fundamental cellular pathways like transcription and replication to fixation of mutations. Cellular misfunctioning, cell death, aging, and cancer are the phenotypical consequences of DNA damages accumulation in the genome. Fortunately, an intricate set of genome surveillance mechanisms function to counteract genomic insults. Among these mechanisms, base excision repair (BER) and nucleotide excision repair (NER) are both dedicated to the removal of single-strand lesions contrary to double-strand break repair (DSBR). Additionally, some specialized polymerases can temporarily take over lesion-arrested DNA polymerases during S phase, in a mutagenic mechanism called translesion synthesis (TLS). Such polymerases only work if a more reliable system, such as homologous recombination (HR), cannot avoid stumbled DNA replication. These DNA repair mechanisms function in conjunction with an intricate machinery of damage sensors, responsible of a series of phosphorylations and chromatin modifications that signal to the rest of the cell the presence of lesions on the DNA. Together DNA repair mechanisms and DNA damage signaling systems form a molecular shield against genomic instability called DNA damage response system (DDR). It is of great importance to understand the molecular mechanism that control DDR and concomitantly disclose the spatiotemporal organization of DDR in the context of nuclear architecture.

We invite authors to present both review articles and original research articles that will stimulate the continuing efforts to understand the mechanisms of DNA repair and recombination. Potential topics include, but are not limited to:

  • Connection between DNA repair pathways and other fundamental cellular processes such as transcription
  • DNA repair and genetic diseases
  • DNA repair and aging
  • Spatiotemporal organization of the DNA damage response and repair
  • Structure-function relationship in DNA repair
  • VDJ recombination

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mbi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 658579
  • - Editorial

DNA in 3R: Repair, Replication, and Recombination

Frédéric Coin | Bernardo Reina-San-Martin | ... | Mark Berneburg
  • Special Issue
  • - Volume 2012
  • - Article ID 598984
  • - Review Article

Genotoxicity Studies Performed in the Ecuadorian Population

César Paz-y-Miño | Nadia Cumbal | María Eugenia Sánchez
  • Special Issue
  • - Volume 2011
  • - Article ID 256063
  • - Review Article

Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer

Kenta Masuda | Kouji Banno | ... | Daisuke Aoki
  • Special Issue
  • - Volume 2011
  • - Article ID 562849
  • - Review Article

Priming DNA Replication from Triple Helix Oligonucleotides: Possible Threestranded DNA in DNA Polymerases

Patrick P. Lestienne
  • Special Issue
  • - Volume 2011
  • - Article ID 542795
  • - Review Article

Nucleotide Excision Repair in Caenorhabditis elegans

Hannes Lans | Wim Vermeulen
  • Special Issue
  • - Volume 2011
  • - Article ID 213824
  • - Research Article

5CAG and 5CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of dNTPs

Emmanuelle Delagoutte | Giuseppe Baldacci
  • Special Issue
  • - Volume 2011
  • - Article ID 718974
  • - Review Article

Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms

Victor D. Martinez | Emily A. Vucic | ... | Wan L. Lam
  • Special Issue
  • - Volume 2011
  • - Article ID 691735
  • - Review Article

Structure and Function of the Small MutS-Related Domain

Kenji Fukui | Seiki Kuramitsu
  • Special Issue
  • - Volume 2011
  • - Article ID 475718
  • - Review Article

Databases and Bioinformatics Tools for the Study of DNA Repair

Kaja Milanowska | Kristian Rother | Janusz M. Bujnicki

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