RASSF Family Proteins
1Molecular Targets Group, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
2Department of Pediatrics, University of Alberta, Edmonton, AB, Canada AB T6G 2N8
3Department of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
4Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-Gu, Daejeon 305-701, Republic of Korea
RASSF Family Proteins
Description
RASSF proteins are a novel family of tumor suppressors whose mechanisms of action remain poorly understood. Most, but not all, family members have been shown to suffer frequent inactivation in human tumors. Indeed, RASSF1A may be the most frequently inactivated tumor suppressor yet identified in human cancer. Several RASSF members have also been implicated as direct Ras oncoprotein effectors that mediate the proapoptotic and growth inhibitory properties of activated Ras. Thus, RASSF proteins may serve as a node for the integration of progrowth and prodeath pathways.
We would like to invite authors to submit research and review papers describing the biological activity and molecular interactions involving RASSF family proteins. Potential topics include, but are not limited to:
- Novel RASSF signaling pathways and interacting partners
- Novel RASSF investigative tools and models
- Functions of RASSF proteins in human disease
- New insights into the epigenetic modulation of RASSF protein expression
Articles published in this special issue will not be subject to the journal's Article Processing Charges.
Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mbi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: