Mediators of Inflammation

Mediators of Inflammation / 1993 / Article

Open Access

Volume 2 |Article ID 193439 |

J. Muntané, Y. Fernandez, S. Mitjavila, M. T. Mitjavila, "Hepatic changes during a carrageenan induced granuloma in rats", Mediators of Inflammation, vol. 2, Article ID 193439, 5 pages, 1993.

Hepatic changes during a carrageenan induced granuloma in rats

Received10 Nov 1992
Accepted08 Dec 1993


Hepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activities measured. The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes.

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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