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Mediators of Inflammation
Volume 2 (1993), Issue 1, Pages 79-83

Hepatic changes during a carrageenan induced granuloma in rats

1Unitat de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Av. Diagonal 645, Barcelona 08028, Spain
2Institut de Physiologie, 2 rue F. Magendie, Toulouse 31400, France

Received 10 November 1992; Accepted 8 December 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activities measured. The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes.