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Mediators of Inflammation
Volume 2, Issue 1, Pages 27-31

Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells

1Institute of Biochemistry, Medical Faculty (Charité), Humboldt University Berlin, Hessische Str. 3-4, Berlin D(O)-1040, Germany
2lnstitute of Veterinary Pharmacology and Toxicology, Free University Berlin, Koserstr., Berlin 33 D-1000, Germany
3Herzog-Julius-Hospital, Kurhausstr, 13–17, Bad Harzburg D-3388, Germany

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl3. It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds.